Those crime rings operate across borders and are making billions of dollars annually, which costs legitimate drug makers a small fortune in lost revenue, AP reports. The World Health Organization estimates that sales of counterfeit, contaminated or illegal medicines total $430 billion a year.

Meanwhile, patients who unknowingly take the counterfeit drugs are often poisoned or get sicker. Experts estimate that thousands of people around the world die because of counterfeit medicines every year.

In developing countries, AP reports, up to 50 percent of the drug supply may be fake.

The companies have pledged nearly $5.9 million over three years to help Interpol with training local law enforcement on investigative procedures, evidence handling and how to work better with partners outside their countries, the article says.

Interpol will also help those local authorities build up  their infrastructure and target enforcement actions against the crime rings, which also divert medication illegally to countries where it isn’t approved.

Counterfeiting has been a difficult arena for Interpol because of the agency’s limited resources, which are often relegated for areas that international community sees as more serious crimes – human trafficking, narcotics dealing, terrorism and money laundering, to name a few.

AP also reports that the pharmaceutical companies will step up sharing intelligence with Interpol. The agency will also run pilot programs, experimenting with new strategies to be more effective.